WINSTON-SALEM, N.C. - John Isner shook off a slow start to beat fellow American Bradley Klahn 7-6 (7-5), 6-2 on Tuesday in the second round of the Winston-Salem Open. Isner, the tournaments top seed and two-time winner, served 13 aces — one clocked at 138 mph — and broke Klahns serve twice in the second set to improve to 11-0 all-time in the final tuneup before next weeks U.S. Open. Three of the top six seeds were eliminated in the second round at the Wake Forest Tennis Center. Third-seeded Tommy Robredo of Spain lost to Frances Nicolas Mahut 6-1, 7-6 (7-0); fourth-seeded Leonardo Mayer of Argentina was upset by Belgian qualifier David Goffin 6-3, 6-1; while Polands Jerzy Janowicz stunned No. 6 seed Joao Sousa of Portugal 6-1, 3-6, 7-6 (7-5). However, No. 2 seed Kevin Anderson of South Africa overcame a shaky second set to beat Frances Adrian Mannarino 6-3, 2-6, 6-4. The 6-foot-8 Anderson, ranked 20th in the world, served 16 aces and almost as many service winners. Mannarino used his ground game to force Anderson into 24 errors in the second set, breaking his serve twice en route to taking the set and evening the match at 1-all. But Anderson got a key service break in the seventh game of the third set, and closed out the match with two aces and a service winner in the deciding game. Robredo, the tournaments third seed, had his serve broken three times in the first set by the 104th-ranked Mahut, who then took four mini-breaks from Robredo in winning the second-set tiebreaker. "I knew he was in for a tough week after Cincinnati," Mahut said of Robredo, who had upset world No. 1 Novak Djokovic of Serbia in advancing to the quarterfinals of last weeks Western and Southern Open. "I knew if I had a good start, it would be difficult for him. The second set was tougher, but it was still a good finish. I had to play more aggressive in the tiebreak, but it was still good." Goffin, who won his first ATP Tour event last month in Kitzbuhel, Austria, extended his winning streak to 24 matches. That includes ATP Challenger Tour event wins in the Netherlands, Poland and Finland. Also advancing were Americans Sam Querry and Donald Young, Edouard Roger-Vasselin of France, Italys Andreas Seppi, Spains Marcel Granollers, Kazakhstans Mikhail Kukushkin, Taiwans Yen-Hsun Lu, Lukas Rosol of the Czech Republic, and Spains Pablo Andujar. Freddy Galvis Jersey . Louis Cardinals continued their offensive tear with a 9-5 victory over the Los Angeles Dodgers in the opener of a four-game series. Cheap Padres Jerseys . Here at TSN.ca we will take a look back at the season by bringing together a panel of experts to help pick the best 50 players of the season. http://www.cheappadresjerseys.com/ . The 25-year-old native of Milford, Conn., has 18 points in 41 games this season. The five-foot-eight 166-pound centre also has 28 points (10-18) in 15 games with AHL Oklahoma City. 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Game five is Wednesday in Toronto where Wade will surely be a target after Toronto fans accused the Chicago, Illinois native of being disrespectful in game three for shooting baskets during the playing of the Canadian national anthem.Wade heard cheers instead of boos on Monday as he tied the score with 12 seconds left by driving to the rim for a basket. Toronto had a chance to ice the win in regulation but Cory Joseph missed a 15-fooot jump shot at the buzzer in front of a crowd of 19,600 fans at Miamis AmericanAirlines Arena.dddddddddddd.Toronto, who played without injured centre Jonas Valanciunas, got scoring from some unexpected sources - 14 points each from DeMarre Carroll and Joseph.Bismack Biyombo started in place of Valanciunas and tallied a double-double with 13 points and 13 rebounds. Valanciunas is out for the rest of the series.But Torontos starting guards were largely ineffective. Kyle Lowry had 10 points and DeMar DeRozan, who was playing with a jammed right thumb, had nine points.Lowry fouled out with 1:58 left in the fourth quarter after he was called for an offensive infraction.Heat big man Hassan Whiteside also skipped Mondays game with a knee injury. His status for game five is uncertain.Veteran Amare Stoudemire started in place of Whiteside. ' ' '